Radix Polygalae Extract Attenuates PTSD-like Symptoms in a Mouse Model of Single Prolonged Stress and Conditioned Fear Possibly by Reversing BAG1
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چکیده
منابع مشابه
Effects of β-Estradiol on Enhanced Conditioned Fear Induced by Single Prolonged Stress and Shock in Rats
Introduction:This study examined the effects of administration of subcutaneous β-estradiol on PTSD-like symptoms (the enhanced conditioned fear response, CFR) that induced by a single-prolonged stress (SPS) and shock in rats. Adult male Wistar rats were exposed to SPS procedure: restraint for 2 h, forced swim for 20 min, and ether anesthesia. Then the rats were placed in fear conditioning syste...
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Fear conditioning studies in adults have found that posttraumatic stress disorder (PTSD) is associated with heightened fear responses and impaired discrimination. The objective of the current study was to examine the association between PTSD symptoms and fear conditioned responses in children from a highly traumatized urban population. Children between 8 and 13 years old participated in a fear ...
متن کاملReduced Consolidation, Reinstatement, and Renewal of Conditioned Fear Memory by Repetitive Treatment of Radix Polygalae in Mice
The therapeutic goal for the treatment of posttraumatic stress disorder (PTSD) is to promote extinction and to prevent the relapse of fearful memories. Research has identified pharmacological treatments that may regulate the formation and extinction of fear memories, but not many reagents that block the relapse of extinguished fear are known. Radix Polygalae (RP) is an Asian herb used for sedat...
متن کاملeffects of β-estradiol on enhanced conditioned fear induced by single prolonged stress and shock in rats
introduction:this study examined the effects of administration of subcutaneous β-estradiol on ptsd-like symptoms (the enhanced conditioned fear response, cfr) that induced by a single-prolonged stress (sps) and shock in rats. adult male wistar rats were exposed to sps procedure: restraint for 2 h, forced swim for 20 min, and ether anesthesia. then the rats were placed in fear conditioning syste...
متن کاملPolygalae Radix Extract Prevents Axonal Degeneration and Memory Deficits in a Transgenic Mouse Model of Alzheimer’s Disease
Memory impairments in Alzheimer's disease (AD) occur due to degenerated axons and disrupted neural networks. Since only limited recovery is possible after the destruction of neural networks, preventing axonal degeneration during the early stages of disease progression is necessary to prevent AD. Polygalae Radix (roots of Polygala tenuifolia; PR) is a traditional herbal medicine used for sedatio...
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ژورنال
عنوان ژورنال: Experimental Neurobiology
سال: 2018
ISSN: 1226-2560,2093-8144
DOI: 10.5607/en.2018.27.3.200